METHODOLOGICAL QUALITY OF RESEARCH ON PERIOPERATIVE IMMUNOMODULATORY SUPPLEMENTATION IN ONCOLOGICAL GASTROINTESTINAL TRACT SURGERY: A META-RESEARCH PROTOCOL

Methodological quality of research on perioperative immunomodulatory supplementation in oncological gastrointestinal tract surgery: a meta-research protocol

Introduction One of the topics that show differences of opinion in the scientific field of nutrition is the recommendation by clinical practice guidelines (CPGs) of an immunomodulatory diet with arginine, nucleotides and omega-3 for individuals diagnosed with cancer undergoing major surgery.The quality of the recommendations is directly related to

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Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation.

Sarcomeres are stereotyped force-producing mini-machines of striated muscles.Each sarcomere contains a pseudocrystalline order of bipolar actin and myosin filaments, which are linked by titin filaments.During muscle development, these three filament types need to assemble into long periodic chains Butter Dishes of sarcomeres called myofibrils.Initi

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